Article

Leveraging single-cell transcriptomics of developing rat ocular outflow tissues to prioritize congenital glaucoma candidate genes

2025-08-29

Abstract excerpt

Primary congenital glaucoma (PCG) is a severe, early-onset eye disease most often caused by abnormal development of the aqueous humor outflow pathway (AHOP). Located circumferentially at the anterior chamber angle where the iris meets the cornea, the AHOP comprises the trabecular meshwork (TM) and Schlemm’s canal (SC), which together regulate intraocular fluid drainage. Malformation of this pathway leads to elevat...

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Literature Corpus work: d2e34132-9bd0-54f1-8612-f40c6a009be6
DOI: 10.1101/2025.08.26.672439

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