Article

Transcriptomic analysis of TGFβ-mediated fibrosis in primary human Tenon’s fibroblasts

2024-03-21

Abstract excerpt

<title>Abstract</title> <p>Glaucoma filtration surgery (GFS) is performed to slow down disease progression in glaucoma, a leading cause of irreversible blindness worldwide. Following surgery, pathological wound healing may lead to conjunctival fibrosis and filtering failure. Myofibroblasts are the key cells responsible for postoperative conjunctival scarring. This study aims to further understand the molecular me...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0ed97442-5b39-5f8e-801b-7d3d4f017dbc
DOI: 10.21203/rs.3.rs-4008732/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transcriptomic analysis of TGFβ-mediated fibrosis in primary human Tenon’s fibroblastsDOI 10.21203/rs.3.rs-4008732/v1Read

Transcriptomic analysis of TGFβ-mediated fibrosis in primary human Tenon’s fibroblastsSemantic proximity Read

Genome-wide RNA-Sequencing analysis identifies a distinct fibrosis gene signature in the conjunctiva after glaucoma surgery.Semantic proximity Read

Genome-wide transcriptome profiling of human trabecular meshwork cells treated with TGF-β2Semantic proximity Read

Genome-Wide Transcriptome Profiling of Human Trabecular Meshwork Cells Treated with TGF-β2.Semantic proximity Read

Genome-Wide RNA Sequencing of Human Trabecular Meshwork Cells Treated with TGF-β1: Relevance to Pseudoexfoliation GlaucomaSemantic proximity Read

RNA-Seq Analysis Unraveling Novel Genes and Pathways Influencing Corneal Wound HealingSemantic proximity Read

Fibrosis-Related Gene and Protein Expression in Normal and Glaucomatous Trabecular Meshwork CellsSemantic proximity Read

Genetic and Protein Expression Profile of Conjunctival Bleb Hyperfibrosis in Early Failure of Glaucoma SurgerySemantic proximity Read

Investigating the miRNA-mRNA interactome of human trabecular meshwork cells treated with TGF-β1 provides insights into the pathogenesis of pseudoexfoliation glaucomaSemantic proximity Read

Transcriptome Changes Driving Multiple Regulatory Pathways Involved in TGF-β-Induced Anterior Subcapsular CataractSemantic proximity Read

Unraveling the role of CLOCK gene in fibrotic skin diseases: insights from single-cell RNA sequencing analysisSemantic proximity Read

Integrative Transcriptomic Analysis of Anterior and Posterior IOP-Controlling Tissues in Glaucoma Reveals Enrichment of MHC-II Pathway and T-Cell Infiltration SignaturesSemantic proximity Read