Article

MAPK Pathway Inhibition Reshapes Kinase Chemical Probe Reactivity Reflecting Cellular Activation States

2025-10-23

Abstract excerpt

Despite the pivotal role of oncogenic kinases in cancer initiation, progression, and therapeutic resistance, functionally profiling their activity and conformational dynamics in live cells remains challenging. Existing methods often fail to capture inhibitor-bound structural states of kinases, particularly in clinically relevant contexts such as treatment response and acquired resistance, where genomic data alone...

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Literature Corpus work: bb8070ba-92be-57de-a6ce-de372928e031
DOI: 10.1101/2025.10.22.684065

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