Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Systematic cysteine scanning identifies a druggable pocket in oncogenic KRAS.

Cell chemical biology - 19 Feb 2026

van Tienen Laurens M, Bayoumi Shadwa, Muneeruddin Khaja, Leymarie Nancy, Popa Alexandra, Shekhar Mrinal, Mueller Madeline, Li Ruitong, Zak Krzysztof M, Chilukuri Harsha, Kornfilt David J P, Atack Thomas C, Kesar Devishi, Bian Yuemin, Shaw Katharin L, Jandova Zuzana, Trollmann Philipp, Geist Leonhard, Stolt-Bergner Peggy, Rumpel Klaus, Kessler Dirk, Sellers William R

Abstract excerpt

The discovery of druggable pockets within proteins that lack traditional active sites remains a significant challenge in the development of therapeutics. To address this, we developed Cysteine Mapping of Accessible Pockets (CysMAP), a method for identifying druggable pockets in proteins. CysMAP employs systematic pooled cysteine (Cys)-variant libraries screened against diverse covalent compound libraries by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding Sites
Share to Cysteine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to KRAS gene

Share to Models, Molecular

Share to Mutation

Share to Proto-Oncogene Proteins p21(ras)

Share to Small Molecule Libraries

Source

Identifiers

PMID: 41679298
DOI: 10.1016/j.chembiol.2026.01.007

Genes

KRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Systematic cysteine scanning identifies a druggable pocket in oncogenic KRAS.PMID 41679298Read ↗

KRAS G12C fragment screening renders new binding pockets.Semantic proximity Read ↗

Covalent targeting of acquired cysteines in cancer.Semantic proximity Read ↗

Exploring switch II pocket conformation of KRAS(G12D) with mutant-selective monobody inhibitors.Semantic proximity Read ↗

KRAS is vulnerable to reversible switch-II pocket engagement in cells.Semantic proximity Read ↗

Beyond KRAS(G12C): Biochemical and Computational Characterization of Sotorasib and Adagrasib Binding Specificity and the Critical Role of H95 and Y96.Semantic proximity Read ↗

Biophysical and structural analysis of KRAS switch-II pocket inhibitors reveals allele-specific binding constraints.Semantic proximity Read ↗

KRAS G12C Drug Development: Discrimination between Switch II Pocket Configurations Using Hydrogen/Deuterium-Exchange Mass Spectrometry.Semantic proximity Read ↗

Pharmacophoric analogs of sotorasib-entrapped KRAS G12C in its inactive GDP-bound conformation: covalent docking and molecular dynamics investigations.Semantic proximity Read ↗

In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C.Semantic proximity Read ↗

Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRASG12C Inhibitor.Semantic proximity Read ↗

The reactivity-driven biochemical mechanism of covalent KRASG12C inhibitors.Semantic proximity Read ↗

Novel druggable space in human KRAS G13D discovered using structural bioinformatics and a P-loop targeting monoclonal antibody.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.