Article

Multiplexed, multimodal profiling of the intracellular activity, interactions, and druggability of protein variants using LABEL-seq

2024-04-20

Abstract excerpt

Multiplexed assays of variant effect are powerful tools for assessing the impact of protein sequence variation, but are limited to measuring a single protein property and often rely on indirect readouts of intracellular protein function. Here, we developed LAbeling with Barcodes and Enrichment for biochemicaL analysis by sequencing (LABEL-seq), a platform for the multimodal profiling of thousands of protein varian...

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Literature Corpus work: 72b7013e-486b-5afb-9fd3-ba9df8de7ea7
DOI: 10.1101/2024.04.19.590094

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