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The long non-coding RNA PCGEM1 is regulated by androgen receptor activity in vivo

20 Feb 2015

Abstract excerpt

BACKGROUND: Long non-coding RNAs (lncRNAs) can orchestrate oncogenic or tumor-suppressive functions in cancer biology. Accordingly, PCGEM1 and PRNCR1 were implicated in progression of prostate cancer (PCa) as transcriptional co-regulators of the androgen receptor (AR). However, these findings were recently refuted asserting that neither gene physically binds to the AR. Despite evidence for differing AR...

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PMID: 25744782
DOI: 10.1186/s12943-015-0314-4

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