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Article

Small Molecule-Induced Domain Swapping as a Mechanism for Controlling Protein Function and Assembly.

Scientific reports - 13 Mar 2017

Karchin Joshua M, Ha Jeung-Hoi, Namitz Kevin E, Cosgrove Michael S, Loh Stewart N

Abstract excerpt

Domain swapping is the process by which identical proteins exchange reciprocal segments to generate dimers. Here we introduce induced domain swapping (INDOS) as a mechanism for regulating protein function. INDOS employs a modular design consisting of the fusion of two proteins: a recognition protein that binds a triggering molecule, and a target protein that undergoes a domain swap in response to binding of the...

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Source

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Identifiers

PMID: 28287617
DOI: 10.1038/srep44388
PMCID: PMC5347425

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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