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Article

The role of subunit assembly in peripherin-2 targeting to rod photoreceptor disk membranes and retinitis pigmentosa.

Molecular biology of the cell - 1 Aug 2003

Loewen Christopher J R, Moritz Orson L, Tam Beatrice M, Papermaster David S, Molday Robert S

Abstract excerpt

Peripherin-2 is a member of the tetraspanin family of membrane proteins that plays a critical role in photoreceptor outer segment disk morphogenesis. Mutations in peripherin-2 are responsible for various retinal degenerative diseases including autosomal dominant retinitis pigmentosa (ADRP). To id...

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Identifiers

PMID: 12925772
DOI: 10.1091/mbc.e03-02-0077
PMCID: PMC181576

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12925772-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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The role of subunit assembly in peripherin-2 targeting to rod photoreceptor disk membranes and retinitis pigmentosa.PMID 12925772Read ↗

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Molecular characterization of peripherin-2 and rom-1 mutants responsible for digenic retinitis pigmentosa.Semantic proximity Read ↗

Peripherin-2 and Rom-1 have opposing effects on rod outer segment targeting of retinitis pigmentosa-linked peripherin-2 mutants.Semantic proximity Read ↗

Multistep peripherin-2/rds self-assembly drives membrane curvature for outer segment disk architecture and photoreceptor viabilitySemantic proximity Read ↗

The Interplay between Peripherin 2 Complex Formation and Degenerative Retinal Diseases.Semantic proximity Read ↗

Photoreceptor Disc Enclosure Is Tightly Controlled by Peripherin-2 Oligomerization.Semantic proximity Read ↗

Transgenic analysis of rds/peripherin N-glycosylation: effect on dimerization, interaction with rom1, and rescue of the rds null phenotype.Semantic proximity Read ↗

An intramembrane glutamic acid governs peripherin/rds function for photoreceptor disk morphogenesis.Semantic proximity Read ↗

Folding and subunit assembly of photoreceptor peripherin/rds is mediated by determinants within the extracellular/intradiskal EC2 domain: implications for heterogeneous molecular pathologies.Semantic proximity Read ↗

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