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Article

ROM1 is redundant to PRPH2 as a molecular building block of photoreceptor disc rims.

eLife - 22 Nov 2023

Lewis Tylor R, Makia Mustafa S, Castillo Carson M, Hao Ying, Al-Ubaidi Muayyad R, Skiba Nikolai P, Conley Shannon M, Arshavsky Vadim Y, Naash Muna I

Abstract excerpt

Visual signal transduction takes place within a stack of flattened membranous 'discs' enclosed within the light-sensitive photoreceptor outer segment. The highly curved rims of these discs, formed in the process of disc enclosure, are fortified by large hetero-oligomeric complexes of two homologous tetraspanin proteins, PRPH2 (a.k.a. peripherin-2 or rds) and ROM1. While mutations in PRPH2 affect the formation of...

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Identifiers

PMID: 37991486
DOI: 10.7554/eLife.89444
PMCID: PMC10665016

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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ROM1 is redundant to PRPH2 as a molecular building block of photoreceptor disc rims.PMID 37991486Read ↗

Photoreceptor Disc Enclosure Is Tightly Controlled by Peripherin-2 Oligomerization.Semantic proximity Read ↗

The Role of Peripherin-2/ROM1 Complexes in Photoreceptor Outer Segment Disc Morphogenesis.Semantic proximity Read ↗

The Interplay between Peripherin 2 Complex Formation and Degenerative Retinal Diseases.Semantic proximity Read ↗

Oligomerization of Prph2 and Rom1 is essential for photoreceptor outer segment formation.Semantic proximity Read ↗

Prph2 initiates outer segment morphogenesis but maturation requires Prph2/Rom1 oligomerization.Semantic proximity Read ↗

A new mouse model for PRPH2 pattern dystrophy exhibits functional compensation prior and subsequent to retinal degeneration.Semantic proximity Read ↗

PRPH2/RDS and ROM-1: Historical context, current views and future considerations.Semantic proximity Read ↗

Rom1 converts Y141C-Prph2-associated pattern dystrophy to retinitis pigmentosa.Semantic proximity Read ↗

ROM1 contributes to phenotypic heterogeneity in PRPH2-associated retinal disease.Semantic proximity Read ↗

Downregulation of rhodopsin is an effective therapeutic strategy in ameliorating peripherin-2-associated inherited retinal disorders.Semantic proximity Read ↗

Deletion of the transmembrane protein Prom1b in zebrafish disrupts outer-segment morphogenesis and causes photoreceptor degenerationSemantic proximity Read ↗

Photoreceptor outer segment disk rim curvature relies on a tetraspanin interaction webSemantic proximity Read ↗

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