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Article

An inducible amphipathic helix within the intrinsically disordered C terminus can participate in membrane curvature generation by peripherin-2/rds.

The Journal of biological chemistry - 12 May 2017

Milstein Michelle L, Kimler Victoria A, Ghatak Chiranjib, Ladokhin Alexey S, Goldberg Andrew F X

Abstract excerpt

Peripherin-2/rds is required for biogenesis of vertebrate photoreceptor outer segment organelles. Its localization at the high-curvature rim domains of outer segment disk membranes suggests that it may act to shape these structures; however, the molecular function of this protein is not yet resolved. Here, we apply biochemical, biophysical, and imaging techniques to elucidate the role(s) played by the protein's...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28325841
DOI: 10.1074/jbc.M116.768143
PMCID: PMC5427266

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