Article

Alternative Anastrozole Target CYP4V2 Impairs Neurons in Preclinical Models of Inherited Tauopathy

2025-11-29

Abstract excerpt

Tauopathies, including Alzheimer disease, are neurodegenerative diseases characterized by the pathological aggregation of the microtubule-associated protein Tau (MAPT). This study explores the neuroprotective properties of anastrozole, a clinical Aromatase inhibitor, in both a Drosophila tauopathy model expressing human MAPT R406W and isogenic pairs of human induced pluripotent stem cell-derived cortical neurons...

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Literature Corpus work: ad00d99f-a600-51f6-8720-74ef42402821
DOI: 10.1101/2025.11.29.689498

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Alternative Anastrozole Target CYP4V2 Impairs Neurons in Preclinical Models of Inherited TauopathyDOI 10.1101/2025.11.29.689498Read

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