Article

Single-molecule cfDNA sequencing establishes clinical utility for ecDNA monitoring and multimodal liquid biopsy analysis

2026-04-09

Abstract excerpt

Cell-free DNA (cfDNA) profiling enables minimally invasive cancer detection and monitoring. We present SIMMA, a low-input single-molecule sequencing approach that enables multimodal whole-genome and high-depth targeted sequencing of the same cfDNA sample for both tumour-agnostic and tumour-informed liquid biopsy analysis. Across 792 plasma and cerebrospinal fluid cfDNA samples from 277 paediatric patients with div...

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Literature Corpus work: 1210e909-98ab-5b3b-a03d-c562fcbd436c
DOI: 10.64898/2026.04.08.26350410

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