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Article

Identification of the MRTFA/SRF pathway as a critical regulator of quiescence in cancer

2024-11-17

Abstract excerpt

Chemoresistance is a major driver of cancer deaths. One understudied mechanism of chemoresistance is quiescence. We used single cell culture to identify, retrieve, and RNA-Seq profile primary quiescent ovarian cancer cells (qOvCa). We found that many qOvCa differentially expressed genes are transcriptional targets of the Myocardin Related Transcription Factor/Serum Response Factor (MRTF/SRF) pathway. We also found...

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Identifiers and source

Literature Corpus work
acd98d9c-d59f-5bbb-98dc-2789ea55f899
DOI
10.1101/2024.11.15.623825
Open publication

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Identification of the MRTFA/SRF pathway as a critical regulator of quiescence in cancerDOI 10.1101/2024.11.15.623825
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