Article

Role of the NuRD complex and altered proteostasis in cancer cell quiescence

2025-02-14

Abstract excerpt

Cytotoxic chemotherapy remains the primary treatment for ovarian cancer (OvCa). Development of chemoresistance typically results in patient death within two years. As such, understanding chemoresistance is critical. One underexplored mechanism of chemotherapy resistance is quiescence. Quiescent cells, which have reversibly exited the cell cycle, are refractory to most chemotherapies which primarily target rapidly...

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Literature Corpus work: 5426f660-ab62-5363-993a-79255e852911
DOI: 10.1101/2025.02.10.637435

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