Article

Single cell resolution of an epigenetic signature of persister tumor cells

2025-04-22

Abstract excerpt

Cancer can recur when a subset of tumor cells, denoted here as persister cells, are able to survive therapy and re-enter the cell cycle. The precise mechanisms that confer the persister state and whether it is characteristic of a subgroup of cells or arises from multiple cellular lineages remain poorly understood. We hypothesize that an epigenetic signature underlies the drug-tolerant persister state, characterize...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cddb9af6-0770-5bbc-a477-5e275b854d9d
DOI: 10.1101/2025.04.16.649175

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single cell resolution of an epigenetic signature of persister tumor cellsDOI 10.1101/2025.04.16.649175Read

Identification and Characterization of Chemotherapy-Resistant High-Risk Neuroblastoma Persister CellsSemantic proximity Read

A prognostic model of drug tolerant persister-related genes in lung adenocarcinoma based on single cell and bulk RNA sequencing dataSemantic proximity Read

The chromatin landscape of high-grade serous ovarian cancer metastasis identifies regulatory drivers in post-chemotherapy residual tumour cellsSemantic proximity Read

Gene Panel of Persister Cells as a Prognostic Indicator for Tumor Repopulation After RadiationSemantic proximity Read

Drug-tolerant persister cell in cancer: reversibility, microenvironmental interplay, and therapeutic strategiesSemantic proximity Read

Single-cell analysis of a high-grade serous ovarian cancer cell line reveals transcriptomic changes and cell subpopulations sensitive to epigenetic combination treatmentSemantic proximity Read

Dormancy, stemness, and therapy resistance: interconnected players in cancer evolutionSemantic proximity Read

Single-cell chromatin accessibility profiling of glioblastoma identifies an invasive cancer stem cell population associated with lower survivalSemantic proximity Read

Cancer cell cycle heterogeneity as a critical determinant of therapeutic resistanceSemantic proximity Read

Drug-Tolerant Persister Cells in Cancer Therapy ResistanceSemantic proximity Read

Analysis of single-cell RNA-sequencing data to identify quiescent and proliferating neural cell populations in GlioblastomaSemantic proximity Read

Single-cell ATAC and RNA sequencing reveal pre-existing and persistent subpopulations of cells associated with relapse of prostate cancerSemantic proximity Read