Article

Transcriptomics informs design of a planar human enterocyte culture system that reveals metformin enhances fatty acid export

2022-01-26

Abstract excerpt

<h4>Background & Aims</h4> Absorption, metabolism, and export of dietary lipids occurs in the small intestinal epithelium. Caco-2 and organoids have been used to study these processes but are limited in physiological relevance or preclude simultaneous apical and basal access. Here, we develop a high-throughput planar human absorptive enterocyte (AE) monolayer system for investigating lipid-handling, then evaluate...

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Literature Corpus work: acc9afda-9e72-5b10-857e-b5c90e1d64c0
DOI: 10.1101/2022.01.24.477515

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