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The development of a functional human small intestinal epithelium model for drug absorption

2 Jun 2021

Abstract excerpt

Advanced technologies are required for generating human intestinal epithelial cells (hIECs) harboring cellular diversity and functionalities to predict oral drug absorption in humans and study normal intestinal epithelial physiology. We developed a reproducible two-step protocol to induce human pluripotent stem cells to differentiate into highly expandable hIEC progenitors and a functional hIEC monolayer...

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PMID: 34078609
DOI: 10.1126/sciadv.abh1586

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