Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SCFAs switch stem cell fate through HDAC inhibition to improve barrier integrity in 3D intestinal organoids from patients with obesity

23 Nov 2023

Abstract excerpt

Stem cells are a keystone of intestinal homeostasis, but their function could be shifted during energy imbalance or by crosstalk with microbial metabolites in the stem cell niche. This study reports the effect of obesity and microbiota-derived short-chain fatty acids (SCFAs) on intestinal stem cell (ISC) fate in human crypt-derived intestinal organoids (enteroids). ISC fate decision was impaired in obesity,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Dietary Effects on Health

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 38125020
DOI: 10.1016/j.isci.2023.108517

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SCFAs switch stem cell fate through HDAC inhibition to improve barrier integrity in 3D intestinal organoids from patients with obesityPMID 38125020Read ↗

Diet-induced alteration of intestinal stem cell function underlies obesity and prediabetes in miceSemantic proximity Read ↗

Key regulators of intestinal stem cells: diet, microbiota, and microbial metabolitesSemantic proximity Read ↗

Gut microbiota: sculptors of the intestinal stem cell niche in health and inflammatory bowel diseaseSemantic proximity Read ↗

The Research Progress on Intestinal Stem Cells and Its Relationship with Intestinal MicrobiotaSemantic proximity Read ↗

Gut microbiota‐stem cell niche crosstalk: A new territory for maintaining intestinal homeostasisSemantic proximity Read ↗

Enteroendocrine cells protect the stem cell niche by regulating crypt metabolism in response to nutrientsSemantic proximity Read ↗

Soluble Siglec-9 Improves Intestinal Barrier Function in a Mouse Model of Metabolic Dysfunction-Associated SteatohepatitisSemantic proximity Read ↗

Modulation of intestinal stem cell homeostasis by nutrients: a novel therapeutic option for intestinal diseasesSemantic proximity Read ↗

Histone 3 lysine 36 trimethylation by SETD2 shapes an epigenetic landscape in intestinal stem cells to orchestrate lipid metabolism and prevent cell senescenceSemantic proximity Read ↗

Glutamine boosts intestinal stem cell-mediated small intestinal epithelial development during early weaning: Involvement of WNT signalingSemantic proximity Read ↗

A tunable human intestinal organoid system achieves controlled balance between self-renewal and differentiationSemantic proximity Read ↗

An iPSC-derived small intestine-on-chip with self-organizing epithelial, mesenchymal, and neural cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.