Employing human intestinal organoids as advanced in vitro models for mechanistic studies on dietary ingredients

Abstract excerpt

Epidemiological studies show that dietary factors significantly impact human health, influencing both harmful and beneficial outcomes in the gastrointestinal tract. In vitro 2D models have been used to study these mechanisms but fail to replicate critical intestinal processes. Human intestinal organoids, which better mimic the cellular complexity of the human intestine, offer a promising alternative. However,...

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