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Pan-cancer screen for mutations in non-coding elements with conservation and cancer specificity reveals correlations with expression and survival

5 Jan 2018

Abstract excerpt

Abstract Cancer develops by accumulation of somatic driver mutations, which impact cellular function. Mutations in non-coding regulatory regions can now be studied genome-wide and further characterized by correlation with gene expression and clinical outcome to identify driver candidates. Using a new two-stage procedure, called ncDriver, we first screened 507 ICGC whole-genomes from 10 cancer types for non-coding...

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PMID: 29354286
DOI: 10.1038/s41525-017-0040-5

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