Article

TOMM40 and TOMM22 of the Translocase Outer Mitochondrial Membrane Complex rescue statin-impaired mitochondrial dynamics, morphology, and mitophagy in skeletal myotubes

2023-06-26

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Statins are the drugs most commonly used for lowering plasma low-density lipoprotein (LDL) cholesterol levels and reducing cardiovascular disease risk. Although generally well tolerated, statins can induce myopathy, a major cause of non-adherence to treatment. Impaired mitochondrial function has been implicated as a cause of statin-induced myopathy, but the underlying mechan...

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Literature Corpus work: acb59200-a7da-5f1c-a6bc-e43b9ffcfe3b
DOI: 10.1101/2023.06.24.546411

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