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Article

The lysosomal membrane protein Sidt2 is a vital regulator of mitochondrial quality control in skeletal muscle.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Apr 2021

Wang Lizhuo, Yu Cui, Pei Wenjun, Geng Mengya, Zhang Yao, Li Zihui, Liang Feiteng, Tan Fengbiao, Du Hui, Gao Jialin

Abstract excerpt

The role of Sidt2 in the process of glucose and lipid metabolism has been recently reported. However, whether Sidt2 is involved in the metabolic regulation in skeletal muscle remains unknown. In this study, for the first time, using skeletal muscle-selective Sidt2 knockout mice, we found that Sidt2 was vital for the quality control of mitochondria in mouse skeletal muscle. These mice showed significantly reduced...

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PMID: 33715196
DOI: 10.1096/fj.202000424R

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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