Article

Mitochondrial membrane proteins and VPS35 orchestrate selective removal of mtDNA.

2021-08-09

Abstract excerpt

<title>Abstract</title> <p>Integrity of mitochondrial DNA (mtDNA), encoding several subunits of the respiratory chain, is essential to maintain mitochondrial fitness. Mitochondria, as a central hub for metabolism, are affected in a wide variety of human diseases but also during normal ageing, where mtDNA integrity is compromised. Mitochondrial quality control mechanisms work at different levels, and mitophagy and...

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Literature Corpus work: b52430cf-7042-587b-84cd-ad4d293bc523
DOI: 10.21203/rs.3.rs-629802/v1

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