Article

Albumin-binding RNAi Conjugate for Carrier Free Treatment of Arthritis

2023-06-04

Abstract excerpt

Osteoarthritis (OA) and rheumatoid arthritis (RA) are joint diseases that are associated with pain and lost quality of life. No disease modifying OA drugs are currently available. RA treatments are better established but are not always effective and can cause immune suppression. Here, an MMP13-selective siRNA conjugate was developed that, when delivered intravenously, docks onto endogenous albumin and promotes pre...

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Literature Corpus work: ac9cea8d-5939-5924-ba9c-ec78fed8c80c
DOI: 10.1101/2023.05.31.542971

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