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Article

A novel therapeutic strategy for cartilage diseases based on lipid nanoparticle-RNAi delivery system

1 Jan 2018

Abstract excerpt

BACKGROUND: Cartilage degeneration affects millions of people but preventing its degeneration is a big challenge. Although RNA interference (RNAi) has been used in human trials via silencing specific genes, the cartilage RNAi has not been possible to date because the cartilage is an avascular and very dense tissue with very low permeability. PURPOSE: The objective of this study was to develop and validate a novel...

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Share to Advancements in Transdermal Drug Delivery
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PMID: 29440889
DOI: 10.2147/ijn.s142797

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