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Matrix-targeted Nanoparticles for MMP13 RNA Interference Blocks Post-Traumatic Osteoarthritis

2020-01-31

Abstract excerpt

Osteoarthritis (OA) is a debilitating and prevalent chronic disease, but there are no approved disease modifying OA drugs (DMOADs), only pharmaceuticals for pain management. OA progression, particularly for post-traumatic osteoarthritis (PTOA), is associated with inflammation and enzymatic degradation of the extracellular matrix. In particular, Matrix Metalloproteinase 13 (MMP13) breaks down collagen type 2 (CII),...

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Literature Corpus work
4c9c3ad1-6a90-5c46-8724-fca16feb0f16
DOI
10.1101/2020.01.30.925321
Open publication

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Matrix-targeted Nanoparticles for MMP13 RNA Interference Blocks Post-Traumatic OsteoarthritisDOI 10.1101/2020.01.30.925321
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