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Amino acid variants at the P94 position in <i>Staphylococcus aureus</i> class A sortase modulate substrate binding and enzyme activity

2026-01-18

Abstract excerpt

The surface of gram-positive bacteria is a highly regulated environment with specific attachment of proteins required for viability. Sortase enzymes are cysteine transpeptidases that recognize and ligate substrates to the peptidoglycan layer in these microorganisms, which can be highly pathogenic (e.g., Staphylococcus aureus, Streptococcus pyogenes, etc.). As such, sortases represent a potentially novel target fo...

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Literature Corpus work
ac97200f-7994-5d10-a14d-2d56bf2a95f0
DOI
10.64898/2026.01.18.700168
Open publication

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Amino acid variants at the P94 position in <i>Staphylococcus aureus</i> class A sortase modulate substrate binding and enzyme activityDOI 10.64898/2026.01.18.700168
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