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Article

Evolution of Streptococcus pyogenes has maximized the efficiency of the Sortase A cleavage motif for cell wall transpeptidation.

The Journal of biological chemistry - 1 Jun 2022

Readnour Bradley M, Ayinuola Yetunde A, Russo Brady T, Liang Zhong, Lee Shaun W, Ploplis Victoria A, Fischetti Vincent A, Castellino Francis J

Abstract excerpt

Trafficking of M-protein (Mprt) from the cytosol of Group A Streptococcus pyogenes (GAS) occurs via Sec translocase membrane channels that associate with Sortase A (SrtA), an enzyme that catalyzes cleavage of Mprt at the proximal C-terminal [-LPST355∗GEAA-] motif and subsequent transpeptidation of the Mprt-containing product to the cell wall (CW). These steps facilitate stable exposure of the N-terminus of Mprt...

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Identifiers

PMID: 35430253
DOI: 10.1016/j.jbc.2022.101940
PMCID: PMC9123276

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