Article

Evolution of Gram+ <i>Streptococcus pyogenes</i> has maximized efficiency of the Sortase A cleavage site

2021-12-22

Abstract excerpt

<h4>ABSTRACT</h4> Human plasminogen (hPg)-binding M-protein (PAM), a major virulence factor of Pattern D Streptococcus pyogenes (GAS), is the primary receptor responsible for binding and activating hPg. PAM is covalently bound to the cell wall (CW) through cell membrane (CM)-resident sortase A (SrtA)-catalyzed cleavage of the PAM-proximal C-terminal LPST ↓ -GEAA motif present immediately upstream of its transme...

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Literature Corpus work: 09081bdd-80af-540a-a9ed-5f6515b03e6a
DOI: 10.1101/2021.12.21.473763

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