Article
Comparing platforms for C. elegans mutant identification using high-throughput whole-genome sequencing.
PloS one - 1 Jan 2008
Shen Yufeng, Sarin Sumeet, Liu Ye, Hobert Oliver, Pe'er Itsik
Abstract excerpt
BACKGROUND: Whole-genome sequencing represents a promising approach to pinpoint chemically induced mutations in genetic model organisms, thereby short-cutting time-consuming genetic mapping efforts. PRINCIPAL FINDINGS: We compare here the ability of two leading high-throughput platforms for paired-end deep sequencing, SOLiD (ABI) and Genome Analyzer (Illumina; "Solexa"), to achieve the goal of mutant detection....
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