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Article

Spatial proximity of tumor-immune interactions predicts patient outcome in hepatocellular carcinoma

19 Sept 2023

Abstract excerpt

BACKGROUND AND AIMS: The fitness and viability of a tumor ecosystem are influenced by the spatial organization of its cells. We aimed to study the structure, architecture, and cell-cell dynamics of the heterogeneous liver cancer tumor microenvironment using spatially resolved multiplexed imaging. APPROACH AND RESULTS: We performed co-detection by indexing multiplexed immunofluorescence imaging on 68 HCC biopsies...

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PMID: 37725716
DOI: 10.1097/hep.0000000000000600

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