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Spatial Proximity of Immune Cell Pairs to Cancer Cells in the Tumor Microenvironment as Biomarkers for Patient Stratification

14 Jul 2025

Abstract excerpt

BACKGROUND/OBJECTIVES: The tumor microenvironment (TME) plays a critical role in cancer progression by shaping immune responses and influencing patient outcomes. We hypothesized that the relative proximity of specific immune cell pairs to cancer cells within the TME could help predict their pro- or anti-tumor functions and reflect clinically relevant immune dynamics. METHODS: We analyzed imaging mass cytometry...

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PMID: 40723219
DOI: 10.3390/cancers17142335

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