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Transcriptomic Mapping of Non-Small Cell Lung Cancer K-RAS p.G12C Mutated Tumors: Identification of Surfaceome Targets and Immunologic Correlates.

Frontiers in immunology - 1 Jan 2021

Alcaraz-Sanabria Ana, Cabañas Morafraile Esther, Fernández-Hinojal Gonzalo, Velasco Guillermo, Pérez-Segura Pedro, Pandiella Atanasio, Győrffy Balázs, Ocaña Alberto

Abstract excerpt

Targeting K-RAS-mutant non-small cell lung cancer (NSCLC) with novel inhibitors has shown promising results with the recent approval of sotorasib in this indication. However, progression to this agent is expected, as it has previously been observed with other inhibitors. Recently, new immune therapeutics, including vectorized compounds with antibodies or modulators of the host immune response, have demonstrated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35178045
DOI: 10.3389/fimmu.2021.786069
PMCID: PMC8843839

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