Back to search

Article

Functional PD-1/PD-L1 engagement defines a spatial biomarker of immunotherapy response

2026-04-17

Abstract excerpt

Effective predictive biomarkers for immune checkpoint inhibitor (ICI) therapy remain an unmet need across solid tumors. Here, we present an integrated spatial proteomics workflow that combines in situ proximity ligation assay with multiplexed immunofluorescence to directly resolve PD-1/PD-L1 signaling events at the level of defined cellular phenotypes and their spatial organization within intact tumor tissue. Ap...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
62a9d357-8a99-512c-adc8-f7260068a9f4
DOI
10.64898/2026.04.15.26350929
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Functional PD-1/PD-L1 engagement defines a spatial biomarker of immunotherapy responseDOI 10.64898/2026.04.15.26350929
Delineating spatial cell-cell interactions in the solid tumour microenvironment through the lens of highly multiplexed imagingSemantic proximity
Defining the microenvironment landscape of bladder cancer using highly multiplexed spatial genomic and proteomic analysisSemantic proximity
Proximity proteome mapping reveals PD-L1-dependent pathways disrupted by anti-PD-L1 antibody specifically in EGFR-mutant lung cancer cellsSemantic proximity
Mapping the Immune Landscape in Metastatic Melanoma Reveals Localized Cell–Cell Interactions That Predict Immunotherapy ResponseSemantic proximity
Proximity proteome mapping reveals PD-L1-dependent pathways disrupted by anti-PD-L1 antibody specifically in EGFR-mutant lung cancer cells.Semantic proximity
From Pixels to Insights: Unveiling Spatial Immune Associations of Immunotherapy Response in Non-Small Cell Lung Cancer using Multiplexed Tissue ImagingSemantic proximity
Mapping the immune landscape in metastatic melanoma reveals localized cell-cell interactions correlating to immunotherapy responsivenessSemantic proximity
A flexible systems analysis pipeline for elucidating spatial relationships in the tumor microenvironment linked with cellular phenotypes and patient-level features.Semantic proximity
Decoding melanoma-immune cell communication through spatially resolved ligand-receptor interaction analysesSemantic proximity
Spatial multi-omics reveal intratumoral humoral immunity niches associated with tertiary lymphoid structures in pancreatic cancer immunotherapy pathologic respondersSemantic proximity
Spatially Resolved Whole-Transcriptomic and Proteomic Profiling of Lung Cancer and Its Immune Microenvironment According to PD-L1 ExpressionSemantic proximity
Multiplex Immunohistochemistry and High-Throughput Image Analysis for Evaluation of Spatial Tumor Immune Cell Markers in Human Breast Cancer: Preliminary Results from the Nashville Breast Health StudySemantic proximity
Select a neighboring publication to make it the new centre.