Article

The BBSome assembly is spatially controlled by BBS1 and BBS4 in human cells

2020-03-20

Abstract excerpt

Bardet-Biedl Syndrome (BBS) is a pleiotropic ciliopathy caused by dysfunction of primary cilia. Most BBS patients carry mutations in one of eight genes encoding for subunits of a protein complex, BBSome, which mediates the trafficking of ciliary cargoes. Although, the structure of the BBSome has been resolved recently, the mechanism of assembly of this complicated complex in living cells is poorly understood. We g...

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Literature Corpus work: e26ab095-a8e2-5650-a84e-b562d4f18104
DOI: 10.1101/2020.03.20.000091

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