Article

R2TP-like Quaternary Chaperones: a comprehensive overview to understand the dynamic R2SP complex

2025-01-28

Abstract excerpt

The human R2SP complex belongs to the R2TP-like quaternary chaperone family and consists of RUVBL1, RUVBL2, SPAG1 and PIH1D2. R2SP is crucial for the correct assembly of motile cilia (SPAG1 null mutations cause Primary Ciliary Dyskinesia) and the organization of the synaptic zone. RUVBL1/2 ATPases are the powerhouse of this molecular machinery, while SPAG1 and PIH1D2 would be adaptors that interact with specific c...

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Literature Corpus work: 04db6604-3b62-5e37-9722-7affde96c0ff
DOI: 10.1101/2025.01.27.635100

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