Structure and activation mechanism of the BBSome membrane-protein trafficking complex

Abstract excerpt

Bardet-Biedl syndrome (BBS) is an incurable ciliopathy caused by the failure to correctly establish or maintain cilia-dependent signaling pathways. Eight proteins associated with BBS assemble into the BBSome, a master regulator of the ciliary membrane proteome. We report the electron cryomicroscopy (cryo-EM) structures of the native bovine BBSome in inactive and active states at 3.1 and 3.5 Å resolution, respectiv...

Topics

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• Bardet-Biedl Syndrome
• Cilia
• Cryoelectron Microscopy
• Microtubule-Associated Proteins
• Models, Molecular
• Mutation
• Protein Binding
• Receptors, G-Protein-Coupled

Identifiers and source

Literature Corpus work

a06eff59-b887-53ec-8494-9084694909c4

DOI

10.1101/849877