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Article

HIV DNA is heavily uracilated, which protects it from autointegration.

Proceedings of the National Academy of Sciences of the United States of America - 31 May 2011

Yan Nan, O'Day Elizabeth, Wheeler Lee Adam, Engelman Alan, Lieberman Judy

Abstract excerpt

Human immune cells infected by HIV naturally contain high uracil content, and HIV reverse transcriptase (RT) does not distinguish between dUTP and dTTP. Many DNA viruses and retroviruses encode a dUTPase or uracil-DNA glycosylase (UNG) to counteract uracil incorporation. However, although HIV virions are thought to contain cellular UNG2, replication of HIV produced in cells lacking UNG activity does not appear to...

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Share to Uracil-DNA Glycosidase
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to CD4-Positive T-Lymphocytes

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Source

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Identifiers

PMID: 21576478
DOI: 10.1073/pnas.1102943108
PMCID: PMC3107311

Genes

UNG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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