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Distribution and fate of HIV-1 unintegrated DNA species: a comprehensive update

16 Feb 2017

Abstract excerpt

Reverse transcription of viral RNA and the subsequent integration of reverse transcripts are the classical early events of the HIV-1 life-cycle. Simultaneously, abundant unintegrated DNAs (uDNAs), are formed in cells ubiquitously. The uDNAs either undergo recombination or degradation or persist inactively for long periods in the nucleus as future resources. Among them, 2-LTR circles are considered a dead-end for...

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PMID: 28209198
DOI: 10.1186/s12981-016-0127-6

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