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Roles of uracil-DNA glycosylase and dUTPase in virus replication

1 Oct 2002

Abstract excerpt

Herpesviruses and poxviruses are known to encode the DNA repair enzyme uracil-DNA glycosylase (UNG), an enzyme involved in the base excision repair pathway that specifically removes the RNA base uracil from DNA, while at least one retrovirus (human immunodeficiency virus type 1) packages cellular UNG into virus particles. In these instances, UNG is implicated as being important in virus replication. However, a...

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PMID: 12237414
DOI: 10.1099/0022-1317-83-10-2339

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