Article

Implication of glomerular endothelial expression of interferon-stimulated gene 20, an antiviral effector protein, in human kidney inflammation

2022-07-19

Abstract excerpt

<h4>Background: </h4> Besides regulating the antiviral response, increased expression of Toll-like receptor 3 (TLR3) in resident renal cells plays a role in the development of some forms of glomerulonephritis. TLR3 activation leads to the production of type I interferon (IFN), which subsequently induces the expression of IFN-stimulated genes (ISGs). We previously reported that in glomerular resident cells, ISG20 e...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ac51e233-cefb-57cf-a703-05f219377592
DOI: 10.21203/rs.3.rs-1770007/v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Implication of glomerular endothelial expression of interferon-stimulated gene 20, an antiviral effector protein, in human kidney inflammationDOI 10.21203/rs.3.rs-1770007/v2Read

Type I IFN in Glomerular Disease: Scarring beyond the STINGSemantic proximity Read

Viral RNA and DNA Trigger Common Antiviral Responses in Mesangial CellsSemantic proximity Read

Innate immunity pathways regulate the nephropathy gene Apolipoprotein L1.Semantic proximity Read

Autoantibodies Against Human Renal Glomerular Endothelial Cells in Lupus Nephritis That Induce Endothelial Interferon-Alpha ProductionSemantic proximity Read

Endothelial <i>GATA6</i> deficiency suppresses intracellular TLR3-interferon signaling in HPAECs and promotes interferon response in HPASMCsSemantic proximity Read

CircRNA-9119 suppresses poly I:C induced inflammation in Leydig and Sertoli cells via TLR3 and RIG-I signal pathwaysSemantic proximity Read

Mechanisms of mesothelial cell response to viral infections: HDAC1-3 inhibition blocks poly(I:C)-induced type I interferon response and modulates the mesenchymal/inflammatory phenotype.Semantic proximity Read

Human acute kidney injury is associated with a proinflammatory phenotypeSemantic proximity Read

Expressions of mRNA for innate immunity-associated functional molecules in urinary sediment in immunoglobulin A nephropathy.Semantic proximity Read

Triggering of TLR3 by polyI:C in human corneal epithelial cells to induce inflammatory cytokinesSemantic proximity Read

Cell cycle arrest in a model of colistin nephrotoxicitySemantic proximity Read

IFN-λ suppresses intestinal inflammation by non-translational regulation of neutrophil function.Semantic proximity Read