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Cell cycle arrest in a model of colistin nephrotoxicity

7 Aug 2013

Abstract excerpt

Colistin (polymixin E) is an antibiotic prescribed with resurging frequency for multidrug resistant gram negative bacterial infections. It is associated with nephrotoxicity in humans in up to 55% of cases. Little is known regarding genes involved in colistin nephrotoxicity. A murine model of colistin-mediated kidney injury was developed. C57/BL6 mice were administered saline or colistin at a dose of 16 mg/kg/day...

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PMID: 23922129
DOI: 10.1152/physiolgenomics.00076.2013

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