Mechanisms of mesothelial cell response to viral infections: HDAC1-3 inhibition blocks poly(I:C)-induced type I interferon response and modulates the mesenchymal/inflammatory phenotype.

doi:10.3389/fcimb.2024.1308362

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Mechanisms of mesothelial cell response to viral infections: HDAC1-3 inhibition blocks poly(I:C)-induced type I interferon response and modulates the mesenchymal/inflammatory phenotype.

Frontiers in cellular and infection microbiology - 1 Jan 2024

Trionfetti Flavia, Montaldo Claudia, Caiello Ivan, Bontempi Giulio, Terri Michela, Tiberi Marta, Marchant Vanessa, Domenici Alessandro, Menè Paolo, Cordani Marco, Zwergel Clemens, Prencipe Giusi, Ruiz-Ortega Marta, Valente Sergio, Mai Antonello, Tripodi Marco, Strippoli Raffaele

Abstract excerpt

Infectious peritonitis is a leading cause of peritoneal functional impairment and a primary factor for therapy discontinuation in peritoneal dialysis (PD) patients. Although bacterial infections are a common cause of peritonitis episodes, emerging evidence suggests a role for viral pathogens. Toll-like receptors (TLRs) specifically recognize conserved pathogen-associated molecular patterns (PAMPs) from bacteria,...

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Identifiers

PMID: 38476167
DOI: 10.3389/fcimb.2024.1308362
PMCID: PMC10927979

Genes

HDAC1
TLR3
CXCL10
CXCL8
STAT1
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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