Article

OligoTRAFTACs: A Generalizable Method for Transcription Factor Degradation

2021-12-21

Abstract excerpt

Dysregulated transcription factors (TFs) that rewire gene expression circuitry are frequently identified as key players in disease. Although several TFs have been drugged with small molecules, the majority of oncogenic TFs are not currently pharmaceutically tractable due to their paucity of ligandable pockets. The first generation of transcription factor targeting chimeras (TRAFTACs) was developed to target TFs fo...

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Literature Corpus work: ac51349f-9497-5317-9009-f82c3ac5e942
DOI: 10.1101/2021.12.20.473482

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