Article

Structures of the human transcription factor brachyury offer insights into DNA recognition, and identify small molecule binders for the development of degraders for cancer therapy

2024-06-06

Abstract excerpt

The transcription factor brachyury is a member of the T-Box family of transcription factors. It is active during embryogenesis and is required for the formation of the posterior mesoderm and the notochord in vertebrates. Aside from its role in embryogenesis, brachyury plays an essential role in tumour growth of the rare chordoma bone cancer and is implicated in other solid tumours. Given that brachyury is minimall...

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Literature Corpus work: b2152118-5a65-54e5-b9ad-1d9bef01df8c
DOI: 10.1101/2024.06.06.597736

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