Targeted Degradation of Transcription Factors by TRAFTACs: Transcription Factor Targeting Chimeras

Abstract excerpt

Many diseases, including cancer, stem from aberrant activation and overexpression of oncoproteins that are associated with multiple signaling pathways. Although proteins with catalytic activity are able to be successfully drugged, the majority of other protein families, such as transcription factors, remain intractable due to their lack of ligandable sites. In this study, we report the development of TRAnscription...

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• CAR-T cell therapy research
• Fluorescence Polarization
• Genes, ras
• I-kappa B Kinase
• Multiple Myeloma Research and Treatments
• Peptidase Inhibition and Analysis
• Protein Degradation and Inhibitors
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

a15db894-fc85-56c7-90ed-417dab2d616e

DOI

10.1101/2020.10.12.336529