Article

Age-related pathological impairments in induced neurons derived from patients with idiopathic Parkinson’s disease

2021-04-23

Abstract excerpt

Understanding the pathophysiology of Parkinson’s disease has been hampered by the lack of models that recapitulate all the critical factors underlying its development. Here, we generated functional induced dopaminergic neurons (iDANs) that were directly reprogrammed from adult human dermal fibroblasts of patients with idiopathic Parkinson’s disease to investigate diseaserelevant pathology. We show that iDANs deriv...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6d8b400e-fb9b-5f28-be97-d99dfff57393
DOI: 10.1101/2021.04.23.441070

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Age-related pathological impairments in induced neurons derived from patients with idiopathic Parkinson’s diseaseDOI 10.1101/2021.04.23.441070Read

Disease‐specific phenotypes in dopamine neurons from human iPS‐based models of genetic and sporadic Parkinson's diseaseSemantic proximity Read

Parallel Neurodegenerative Phenotypes in Sporadic Parkinson’s Disease Fibroblasts and Midbrain Dopamine NeuronsSemantic proximity Read

Distinct sub-cellular autophagy impairments occur independently of protein aggregation in induced neurons from patients with Huntington’s diseaseSemantic proximity Read

Distinct subcellular autophagy impairments in induced neurons from patients with Huntington's diseaseSemantic proximity Read

Age-related Huntington’s disease progression modeled in directly reprogrammed patient-derived striatal neurons highlights impaired autophagySemantic proximity Read

Human iPSC-based modeling of late-onset disease via progerin-induced aging.Semantic proximity Read

Parallel neurodegenerative phenotypes in sporadic Parkinson's disease fibroblasts and midbrain dopamine neurons.Semantic proximity Read

Autophagy Dysfunction in iPSCs-Derived Neurons and Midbrain Organoids Carrying a <i>SNCA</i> TriplicationSemantic proximity Read

Modeling Cell-Cell Interactions in Parkinson’s Disease Using Human Stem Cell-Based ModelsSemantic proximity Read

Recapitulating Parkinson’s pathology in human iPSC dopaminergic neurons reveals new mechanistic insights into Lewy body formation and heterogeneitySemantic proximity Read

Direct Reprogramming Retains Aging Signatures That Are Critical to Reveal Parkinson's Disease-Associated Autophagy Phenotypes.Semantic proximity Read

Modeling Parkinson’s Disease Using Induced Pluripotent Stem CellsSemantic proximity Read