Deep phenotyping of peripheral tissue facilitates mechanistic disease stratification in sporadic Parkinson's disease.

doi:10.1016/j.pneurobio.2020.101772

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Article

Deep phenotyping of peripheral tissue facilitates mechanistic disease stratification in sporadic Parkinson's disease.

Progress in neurobiology - 1 Apr 2020

Carling Phillippa J, Mortiboys Heather, Green Claire, Mihaylov Simeon, Sandor Cynthia, Schwartzentruber Aurelie, Taylor Rosie, Wei Wenbin, Hastings Chris, Wong Siew, Lo Christine, Evetts Samuel, Clemmens Hannah, Wyles Matthew, Willcox Sam, Payne Thomas, Hughes Rachel, Ferraiuolo Laura, Webber Caleb, Hide Winston, Wade-Martins Richard, Talbot Kevin, Hu Michele T, Bandmann Oliver

Abstract excerpt

Mechanistic disease stratification will be crucial to develop a precision medicine approach for future disease modifying therapy in sporadic Parkinson's disease (sPD). Mitochondrial and lysosomal dysfunction are key mechanisms in the pathogenesis of sPD and therefore promising targets for therapeutic intervention. We investigated mitochondrial and lysosomal function in skin fibroblasts of 100 sPD patients and 50...

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PMID: 32058042
DOI: 10.1016/j.pneurobio.2020.101772

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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