Article

SPG11 models reveal lysosomal calcium as a regulator of neural progenitor proliferation

2025-07-21

Abstract excerpt

Lysosome dysfunction has been widely implicated in many models of neurodegeneration, but much less is understood of its involvement during brain development in health and disease. Hereditary spastic paraplegia caused by mutations in the SPG11 gene is a neurodegenerative disorder characterized by lysosome dysfunction, which also presents neurodevelopmental alterations. Using knockout mouse and cortical organoid mo...

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Literature Corpus work: 46f7a0af-b3b0-5a0b-8055-35eeeacb2be9
DOI: 10.1101/2025.07.21.665525

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