Article

Matrix structure and microenvironment dynamics correlate with chemotherapy response in ovarian cancer

2025-05-24

Abstract excerpt

Elevated extracellular matrix (ECM) in the tumor microenvironment (TME) is associated with chemoresistance and poor prognosis. We hypothesized that modifying the ECM may enhance response to chemotherapy. We measured chemotherapy-induced changes in the TME of two mouse models of high-grade serous ovarian cancer (HGSOC) that differed in chemotherapy response. Treatment of the chemo-sensitive tumors triggered dynamic...

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Literature Corpus work: ac20c069-2266-5473-98f1-3b19e0e7df26
DOI: 10.1101/2025.05.19.654864

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